{"id":9463,"date":"2024-10-22T12:17:23","date_gmt":"2024-10-22T10:17:23","guid":{"rendered":"https:\/\/letscureacc.com\/?post_type=glossary&#038;p=9463"},"modified":"2024-10-22T12:17:28","modified_gmt":"2024-10-22T10:17:28","slug":"syndrome-de-li-fraumeni-lfs","status":"publish","type":"glossary","link":"https:\/\/letscureacc.com\/fr\/glossaryindex\/syndrome-de-li-fraumeni-lfs\/","title":{"rendered":"Syndrome de Li-Fraumeni (LFS)"},"content":{"rendered":"\n<p>Le LFS est \u00e9troitement associ\u00e9 aux mutations du g\u00e8ne TP53, qui joue un r\u00f4le central dans le contr\u00f4le de la division cellulaire et de la mort cellulaire. Lorsque TP53 mute, la capacit\u00e9 de l&rsquo;organisme \u00e0 r\u00e9parer les dommages cellulaires est consid\u00e9rablement alt\u00e9r\u00e9e, ce qui entra\u00eene une susceptibilit\u00e9 beaucoup plus \u00e9lev\u00e9e \u00e0 de nombreux types de cancers.<br>Dans le LFS, le corticosurr\u00e9nalome a tendance \u00e0 se manifester pendant l&rsquo;enfance. Environ 6 \u00e0 13 % des enfants atteints du LFS d\u00e9veloppent un cancer de la glande surr\u00e9nale, souvent entre 1 et 4 ans.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Le LFS est \u00e9troitement associ\u00e9 aux mutations du g\u00e8ne TP53, qui joue un r\u00f4le central dans le contr\u00f4le de la division cellulaire et de la mort cellulaire. Lorsque TP53 mute, la capacit\u00e9 de l&rsquo;organisme \u00e0 r\u00e9parer les dommages cellulaires est consid\u00e9rablement alt\u00e9r\u00e9e, ce qui entra\u00eene&#8230;<\/p>\n","protected":false},"author":416,"featured_media":0,"menu_order":0,"template":"","meta":{"give_campaign_id":0,"inline_featured_image":false,"footnotes":""},"glossary-categories":[],"glossary-tags":[],"class_list":["post-9463","glossary","type-glossary","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/letscureacc.com\/fr\/wp-json\/wp\/v2\/glossary\/9463","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/letscureacc.com\/fr\/wp-json\/wp\/v2\/glossary"}],"about":[{"href":"https:\/\/letscureacc.com\/fr\/wp-json\/wp\/v2\/types\/glossary"}],"author":[{"embeddable":true,"href":"https:\/\/letscureacc.com\/fr\/wp-json\/wp\/v2\/users\/416"}],"version-history":[{"count":0,"href":"https:\/\/letscureacc.com\/fr\/wp-json\/wp\/v2\/glossary\/9463\/revisions"}],"wp:attachment":[{"href":"https:\/\/letscureacc.com\/fr\/wp-json\/wp\/v2\/media?parent=9463"}],"wp:term":[{"taxonomy":"glossary-categories","embeddable":true,"href":"https:\/\/letscureacc.com\/fr\/wp-json\/wp\/v2\/glossary-categories?post=9463"},{"taxonomy":"glossary-tags","embeddable":true,"href":"https:\/\/letscureacc.com\/fr\/wp-json\/wp\/v2\/glossary-tags?post=9463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}