This is a rare disorder of the adrenal glands. It occurs when the body doesn’t produce enough of certain hormones (often cortisol and aldosterone). It occurs in ACC patients having their adrenal gland(s) removed and undergoing treatment like Mitotane (that suppresses the function of adrenal glands). As a result, treatment to supplement the missing hormones that the body can no longer produce is required as long as needed. Patients suffering from adrenal insufficiency must be aware and look out for the signs of adrenal crisis.