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Known as one of the most powerful tools to predict the risk of recurrence and therefore patients’ survival. It is to be included in standard work-up of ACC patients. There are three levels of Ki67, expressed in percentages. The greater the number is, the worse the prognosis.

– grade 1 tumors with Ki67 <10%
– grade 2 with Ki67 10–19%
– grade 3 tumors with Ki67 ≥20%

Source : Adrenocortical carcinoma: differentiating the good from the poor prognosis tumors